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Biotech / Medical : Ionis Pharmaceuticals (IONS)

IONS 81.94

-0.3%

Jan 28 3:59 PM EST

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To: marc ultra who wrote (1931)	4/22/1998 12:45:00 PM
From: tommysdad	Read Replies (2) of 4676

"first antisense NDA" For a dissenting opinion on that, see: biofind.com Any of the ISIS-following biology experts have an opinion on this? Has the mechanism of action of formavirsen been demonstrated unequivocally to be via an antisense "pathway"? Has it been demonstrated to NOT be antisense, as this guy claims? Any references to peer-reviewed articles would be appreciated. I am not knowing here, just asking. While the mechanism of action will not affect sales of this drug, it does sort of impact the whole concept of ISIS's drug discovery paradigm.

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