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Biotech / Medical : Ionis Pharmaceuticals (IONS)
IONS 81.94-0.3%Jan 28 3:59 PM EST
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To: sds who wrote (1949)4/25/1998 3:25:00 AM
From: marc ultra  Read Replies (1) of 4676
 
Many of your points are good but we must make a clear distinction between Crohn's and ulcerative colitis. Crohn's is generally not considered curable by surgery and when you cut some out you often get inflammation somewhere else so surgery is usually reserved for acute problems like megacolon and possible perforations. Ulcerative colitis in the other hand is considered curative with proper and extensive removal of the colon and surgical techniques have improved so quality of life usually pretty good. One reason why ulcerative colitis patients opt for surgery is there is a very high probability of developing colon cancer in these patients which increases with time and extent of activity and even in good situations usually requires relatively frequent colonoscopies to monitor for cancer or precancerous polyps. This situation is not as big a deal with Chrohn's. Based on this a Chrohn's patient wants a drug treatment and especially would want a drug that would limit the need for corticosteroid use. An ulcerative colitis patient however looking at the high probability of colon cancer and knowing that appropriate surgery is both curative of his colitis and practically eliminates the constant worry of colon cancer reasonably often opts for surgery.
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