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Biotech / Medical : Zonagen (zona) - good buy?
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To: LoLoLoLita who wrote (3677)4/30/1998 11:44:00 AM
From: Jacques Chitte  Read Replies (1) of 7041
 
I believe the proposed dose is 40 mg of the mesylate - I don't know if that is gross or net (40 mg base equivalent - there's a 30% dose difference).
My Sigma catalog (fine chemicals and biochemicals)ts phentolamine mesylate as $116 for half a gram. That's quite a bill of materials if major economies of scale are absent. And for all I know Zonagen follows the "fabless" model and will need a contractor to whip up a few kg at a time of the good stuff.
I do not have any knowledge of an active ingredient other than phentolamine. I believe the tablet contains a proprietary disintegrant/dispersant to try to approach the pharmacokinetics of a glass of solution. But that's hardly a new trick.

I will have to sit tight and wait for meaningful news regarding the Phase III trials and/or the NDA app.
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