SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Zonagen (zona) - good buy?
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: LoLoLoLita who wrote (3699)4/30/1998 3:18:00 PM
From: Jacques Chitte  Read Replies (1) of 7041
 
Speeding up delivery of oral meds is a tricky business. You have the unavoidable delay of crossing the stomach wall and passing the liver's inspection. Buccal/sublingual is quick, but this works only for a few potent, lipophilic compounds. Phentolamine is too basic and lipophobic to quickly cross the mucosa, compared to like nitroglycerin or atropine.
My Merck Index says of phentolamine mesylate, "Aqueous solns cannot be stored." So a predissolved form would be problematic.

I'd favor a suppository. The mechanical action alone oughtta do the trick for some of the patient population.

I know. Let's patent the Vibrating Phentolamine Suppository, and get real rich. :-)
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News