Biotime-Nasdaq's best kept secret? Message Board

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Biotech / Medical : Biotime-Nasdaq's best kept secret?

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Nov 5 1:26 PM EST

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To: Mark A. Voelker who wrote (883)	5/1/1998 1:11:00 AM
From: Stephen How	Read Replies (1) of 1432

Mark, I'll try to get a copy of the Bick paper from Biotime. I contacted the publisher for reprints, but haven't yet received it. There have been many papers studying the effect of hydroxyethyl starch (HES) on coagulation (http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?form=4&db=m&term=hetastarch%5DAND+coagulopathy&dispmax=100&relpubdate=No+Limit). Hetastarch induced coagulopathy is the big issue here! This is at the center of the whole controversy over the added-value of Hextend&reg over Hespan&reg! I hope there is no confusion over this! If Bick concluded there was no HES induced coagulopathy, then it only categorizes him in the "no coagulation effect" category (recall the 4/18 other "no effect" studies). I think I've stated my views on Hextend&reg clearly here, and on my webpage. My estimation of the product, the stock, and the controversy have been constant since I started my webpage. All of the facts and developments surrounding this stock seem perfectly consistent to me. Even though people seem to express dismay over the recent events, I'm pretty sure everyone understands the doubts about the product's value. Steve btim.dyn.ml.org P.S. The Anesth Analg paper did not cite the Bick paper. It cited 43 references, including the 3 specific references for the HES coagulopathy mechanism paragraph. The Bick paper wasn't cited, since it was not an original reference on HES, except for it's study of Hextend&reg.

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