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Biotech / Medical : Ligand (LGND) Breakout!
LGND 203.64+2.3%12:39 PM EST

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To: Flagrante Delictu who wrote (19979)5/4/1998 4:18:00 PM
From: tonyt  Read Replies (1) of 32384
 
In case you missed it:

messages.yahoo.com@m2.yahoo.com
dnarnaprotein
May 4 1998
12:10PM EDT

Dear Bernie,

Yipes. What's wrong with posting an opinion? And it's just my opinion, but it seems a bit odd to respond at length on SI (http://www3.techstocks.com/~wsapi/investor/reply-4304043) to a Yahoo posting. Please feel free to respond to this message [on Yahoo]. And I apologize for cluttering up the Yahoo board with this response.

FYI, Evans uses the term "nuclear receptor" to describe a member of this superfamily. The major meeting on this topic is sponsored every other year by the Keystone Symposia, and he was one of three organizers of the most recent (March 28 - April 3, 1998, at Lake Tahoe), entitled "Nuclear Receptor Gene Family." For one of many recent examples of an Evans citation using this term see:
ncbi.nlm.nih.gov

As for Henry's scientific efforts, I knew that he had never published a scientific paper on nuclear receptors, but was leaving open the possibility that he actually did have some direct experience, perhaps when Ligand was starting up.

As for whether I am the <<dearly departed "Courtney">> or any of the other candidates, the answer is no. You're right that I don't really have the time to waste posting messages on these boards, and this is my second.

As for the Glaxo/Wellcome investment in structural determination, this was based on their presentations at several recent scientific meetings of the x-ray crystal structures of an interesting nuclear receptor called PPAR, which is involved in lipid metabolism. Presumably these structures will be published soon, but companies are slow.

Finally, I have to say that I feel like Web Hubbell, whose more positive comments on Hillary were edited out in the transcripts released by the VRWC. To reiterate, my opinion is that "the science at Ligand is strong, and the science in his (Henry's) posts is generally both accurate and articulately described." Among scientists, this is certainly more than faint praise.
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