SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Neopath (NPTH)
NPTH 0.0006000.0%Mar 7 3:00 PM EST
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: Cytotekk who wrote (135)5/6/1998 10:19:00 PM
From: Sigmund  Read Replies (1) of 178
 
Would you please then address the following points:

1. It looks to me like a 25% sort rate is really a bit lower since it requires 15% QC rather than 10%. 15% of 75% is 11.2 QC slides rather than 10 per hundred so the 25% sort rate really turns out to be 23.8%. Do we agree on this rather technical and not so important point?

2. Now how does primary screening have a positive diagnostic impact as compared to secondary screening? It seems to me that with secondary screening, every slide is first read by a tech and then the computer picks out those that are most likely to have a problem. Thus these problem slides are read twice.

With primary screening, the computer eliminates the most likely negative slides and sequences the remaining by likelihood of there being a problem. But now how do you select slides for quality control rescreening? If you pick the top 15% most likely as per AutoPap for rescreening you really are ignoring the others because it is the top 15% which (because of the ordering by AutoPap) got the most attention from the techs in the first place. This would seem to have built in some sort of management problem in the long run i.e. poor lab practice on the slides not sorted out by AutoPap but not designated by AutoPap as being the most likely to be positive.

How do you determine if the machine is working properly? Is there any sampling and manual reading of the slides sorted out by AutoPap? If not this would seem to be a major disaster just waiting to happen. If AutoPap is malfunctioning, potentially positive slides might be in error sorted out. If there is sampling and reading from that group it really reduces the effective sort rate further.

Do any of my points and questions make any sense to you? or am I totally off-base here?
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News