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Biotech / Medical : Paracelsian Inc (PRLN)
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To: paul goldstein who wrote (3590)5/7/1998 6:57:00 PM
From: Elllk  Read Replies (3) of 4342
 
To all:

Hindsight and the incredible attention given to EntreMed with its angiostatin and endostatin drug combination, which wipes out cancer tumors in mice, indicate that the new management of PRLN did make a mistake in not giving more attention to Androcar in the 1997 report. Angiostatin and endostatin work in combination to stop the blood supply to tumors and is referred to as starving the tumors. The PRLN 1996 Annual Report, re AndroCar, states "It is also believed that AndroCar tm inhibits proliferation of blood vessels and that this may attack solid tumors in a manner different from current cancer therapeutics. This effect may occur as a result of inhibiting the growth of the tumor cells and small blood vessels into the tumor mass. This latter effect may restrict the food supply of the tumor and leads to starvation of the tumor cells." This information is left out of the 1997 Annual Report which barely mentions AndroCar and AndroVir. And clearly none of the real big spenders has picked up on the possibilities, herein, for PRLN and AndroCar, which would seem to be as good as any of these other companies getting attention such as the Swedish company Oxigene which is jumping on the bandwagon with their man made derivative of the extract of the African bush willow called Combrestatin A4 which they will start testing on people in November. AndroCar has already had some human testing. It seems to me that PRLN management should try to make some noise here.

Larry
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