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CANCERLITr Bibliographic Database Detailed Search Results
Record 6
UNIQUE ID: 98153903
AUTHOR: Hamad GG, Neifeld JP
TITLE: Biochemical, hematologic, and immunologic alterations following hepatic cryotherapy.
SOURCE: Semin Surg Oncol; 14(2):122-8 1998
ABSTRACT: Hepatic cryosurgery causes hepatocellular damage primarily by inducing the formation of ice crystals. Cell necrosis is enhanced using two or more freeze-thaw cycles. The resultant damage to hepatocytes induces alterations in a number of biochemical and hematologic parameters, including hepatic function tests, serum bilirubin, serum and urine myoglobin, platelet count, and coagulation measures. Further, in experimental models, cryogenic surgery appears to stimulate the immune system of the host leading to an anti-tumor immune response. These perturbations in biochemical and hematologic parameters are usually transient, and long-term adverse sequelae are uncommon and preventable. (23 Refs)
MESH TERMS: Animal
Antigens, Neoplasm/Blood
Cryosurgery*/Adverse Effects
Human
Liver Function Tests
Liver Neoplasms/Blood/Immunology/*Metabolism/*Surgery/Urine
Myoglobin/Blood
Myoglobinuria/Etiology
T-Lymphocytes/Immunology
Thrombocytopenia/Etiology
Tumor Markers, Biological/Blood
LANGUAGE: ENG
PUBLICATION TYPE: JOURNAL ARTICLE
REVIEW
REVIEW, TUTORIAL
TITLE ABBREVIATION: Semin Surg Oncol
YEAR: 98
ADDRESS: Department of Surgery, Virginia Commonwealth University 23298, USA.
ENTRY MONTH: 9804
CAS NO.: 0 (Antigens, Neoplasm)
0 (Myoglobin)
0 (Tumor Markers, Biological)
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