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Biotech / Medical : PE Biosystems (PEB)

PEB 12.04

-2.5%

Jan 14 3:59 PM EST

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To: Richard Haugland who wrote (38)	5/12/1998 7:02:00 AM
From: Richard Haugland	Read Replies (3) of 122

From the even later post on PKN biz.yahoo.com it seems apparent that the PKN acceleration of sequencing is due to the use of capillary electrophoresis rather than larger gel electrophoresis. Although I don't know much about the company, I don't believe that Hyseq has any technology in this area. The pertinent quotes Tony White, chairman and chief executive officer of Perkin-Elmer, said he thought his company's new gene sequencing technology could get the genome sequenced within three years. ''It is a system that is more highly automated, runs faster, more efficiently with less manpower required to attend the instrument,'' he said. ''It runs 24 hours a day.'' The old technology uses a gel-like material that has an electric current running through it. This separates out the DNA pieces by size -- but the little slab of gel must be changed by a technician between each batch. New ''capillary'' technology uses a long, thin tube pumped full of a liquid polymer that can be changed automatically. Note: I believe that the capillary electrophoresis technology used in this sequencer is probably part of the subject of the PKN suit of Amersham/Molecular Dynamics.

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