Frostman or anyone, below is the abstract I still cannot see it.
OK, There were 115 men and 27% got success
Thus 115 x 0.27 = 31 successes
Therefore 115-31 = 84 failures, these must have failed on 250ug
Of these, 84 x 0.17 = 14 then succeeded on 500ug
Then 4 of 10 failing on 500ug subsequently succeeded on 1000ug
Thus the number succeeding overall is 4 + 14 + n = 31
n = 13, this must be the number succeeding on 250ug
But then 13 + 84 not equal to 115 (credit to lpmost on the yahoo thread for pointing this out).
So, can we get it by assuming that some men dropped out during the experiment and/or more than 115 started - I'll look? Weird abstract.
Sorry the balls up after shooting my mouth off - that'll teach me.
DaiS
*****
115 men aged 64.8ñ10.6 with regular sexual partner were treated in a manner patterned after the initial NEJM
report. They were in general well educated with 50.9%. college and 28.9% postgraduate education. Self rating of
genera health resulted in a mean of 8.1 (scare from 1-10), and of sexual function in a mean of 3.5 (1-10). Status
post prostatectomy and diabetes were the most common etiologies. In-office treatment with increasing doses of
MUSE were conducted with self-rating of penile rigidity (1-5, 4 and 5 being sufficient for intercourse) and level
of comfort (1-5) as well as blood pressure checks in 15 min intervals.
RESULTS:
Peak rigidities were achieved at 30 min with means of 2.6 (250 mcg), 2.4 (500 mcg), and 2.9 (1000 mcg). Only
27% of pts achieved rigidity sufficient for intercourse despite being challenged to the highest dose. Of those pts
who failed on 250 mcg, 17% achieved a level 4 or 5 with 500 mcg, and of those 10 failing on 500 mcg only 4
achieved such level with 1000 mcg. Discomfort was maximal at 15 min with means of 3.5 (250 mcg), 3.7 (500
mcg), and 4.2 (1000 mcg). Blood pressure decreased significantly at 15 and 30 min. and orthostatic hypotension
(decrease by >20 mmHg at 30 min) occurred in 6.%. Penile pain and burning with 41% each were the most
common adverse events, followed by dizziness (14%). There was no significant interaction between mean rigidity
scores and age or etiologies. Most disappointing is the fact that at follow-up only 18.6% of pts continue the use
of the MUSE system, while the majority have chosen alternative treatment forms, citing disappointment with the
results and cost as the most important reasons for dicontinuation
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