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Biotech / Medical : SANGUINE CORP. (SGNC)
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To: Profiteer who wrote ()6/15/1998 1:49:00 AM
From: sdheart   of 5402
 
HELP FOR HEART ATTACK

Biomater Artif Cells Immobilization Biotechnol 1992;20(2-4):941-949

Extended use of Fluosol emulsion in acute myocardial ischemia treatment.

Ohyanagi H, Saitoh Y, Uchida T, Watanabe M, Yamanouchi K, Yokoyama K, Mitsuno T

First Department of Surgery, School of Medicine Kobe University, Japan.

An intravenous infusion of Fluosol enhanced significantly the t-PA thrombolysis of the
arterio-venous shunt made by insertion of 125I-fibrin clot in rabbits. The plasma
radioactivity released through thrombolysis increased in both time and dose-dependent
manner after the administration of t-PA. Fluosol in combination with t-PA increased the
plasma radioactivity, compared with the t-PA treatment alone at the corresponding
dosage. The coronary blood flow was markedly reduced to almost zero after the thrombin
injection into narrowed LCX with a clamp in open-chest dogs. An intravenous infusion of
Fluosol or Pluronic F-68 solution at a dose of 15 ml/kg significantly shortened the
thrombolysis time by intracoronary infusion of urokinase alone. While, little change in the
QTc interval of ECG and the plasma CPK-MB activity was observed in the Fluosol group
in combination with urokinase, suggesting a myocardial protective action of Fluosol
possibly due to its oxygen carrying effect.

sdheart
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