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Biotech / Medical : SANGUINE CORP. (SGNC)
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To: Prospector who wrote (1753)6/25/1998 7:51:00 PM
From: chirodoc   of 5402
 
186 SURGICAL PATIENTS--NO NEGATIVE REACTIONS!!!!
EXCEPT ONE PATIENT--LONG TERM USE

Ann Surg 1982 Jan;195(1):60-69

Clinical studies of a perfluorochemical whole blood substitute (Fluosol-DA) Summary of 186 cases.

Mitsuno T, Ohyanagi H, Naito R

After the experimental and phase one studies of our so-called "artificial blood," Fluosol-DA (20%), an emulsified mixture of perfluorodecalin and perfluorotripropylamine, were successfully completed, phase two and three clinical studies were carried out on 186 patients in Japan. The initial dose was 20 ml/Kg body weight (BW), and additional 10 ml/Kg BW doses were applied as needed. Oxygen-supplying and plasma-extending effects were established. No untoward reaction was observed in any of the 186 cases except in a case that involved long-term repeated administration. Initial studies on FLuosol-DA suggest reasonable safety; however, additional clinical trials appear warranted.
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