Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 202.50

-2.7%

Nov 7 3:59 PM EST

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To: WTDEC who wrote (22697)	6/26/1998 9:17:00 AM
From: Henry Niman	Read Replies (1) of 32384

Yesterday Bear Stearns mentioned LGND in their Biotech Watch report. Under Clinicals, they said: "Ligand (LGND) reported on June 23 that the company has discovered two compounds which appear to mimic the effects of progesterone without related side effects. In the article appearing in the Journal of Medicinal Chemistry, data from animal studies demonstrated that the two compounds were able to selectively stimulate certain tissue types such as uterine tissue. Natural progesterone supplements are know to be beneficial to women on hormone replacement therapy and those trying to conceive children through the hormone's action on the uterus, However, progesterone is also believed to stimulate breast tissue growth, which can lead to breast cancer. In the animal data presented, both of the LGND compounds worked better than mifepristone - a synthetic progestin - on maintaining pregnancy and increasing uterine thickness while having six to nine times less stimulation activity on breast tissues."

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