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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: scaram(o)uche who wrote (4620)6/29/1998 11:45:00 PM
From: Biomaven  Read Replies (1) of 6136
 
Rick,

Here's a quote from an article (Truncal Obesity, "Crix-Belly" - Is it what it appears to be.or something else?) earlier this year suggesting that PI's are not the only culprit:

The major weakness in this hypothesis, that the changes represent a toxic, metabolic effect caused by protease inhibitors, is that some patients with the syndrome are not taking protease inhibitors. Investigators from San Francisco reported that the development of a Buffalo hump was not limited to patients receiving protease inhibitor therapy. In addition, we have also observed several patients in New York with the "syndrome" who were not taking protease inhibitors and their plasma viral burdens were low. We have been evaluating the ability of anthropometric measurements to detect the alterations in fat distribution, since data on a large number of HIV+ and control subjects studied since 1984 are available. Based on this data, there is preliminary evidence that altered fat distribution was a common phenomenon in HIV-infected subjects studied in the past, prior to the availability of protease inhibitors. Even among this study group, a few patients were seen who were identical to those being described as having the "syndrome."

Full article is at:

healthcg.com

Peter
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