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Biotech / Medical : AFFYMETRIX (AFFX)

AFFX 14.01

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Apr 1 5:00 PM EST

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To: Richard Haugland who wrote (741)	6/30/1998 1:43:00 AM
From: jpbrody	Read Replies (2) of 1728

Richard, thanks for posting that patent info. I wasn't aware of that one. Just one question for you, why do you interpret the "attached" to mean "covalently attached"? I'm not much of a chemist, but I thought that the Hyseq method is more of a non-specific adsorption to the surface, which I wouldn't call covalent, but I would call attached. From the patents I've looked at in this field, mostly hyseq and nanogen, I don't see any problems for affymetrix. Hyseq has some patents on sequencing by hybridization, which was the big application for these chips five years ago, but is almost irrelevant these days. Nanogen is off in a parallel universe. They seem to be working more on low density arrays using their electric fields to provide rapid results when testing for specific infectious microbes. It's much more of a hospital lab test than a genomics platform.

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