Agouron Pharmaceuticals (AGPH) Message Board

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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Peter Singleton who wrote (4678)	7/1/1998 1:55:00 PM
From: Vector1	of 6136

Peter, My understanding is that JE-2147 was licensed by AGPH because in vitro, it was fully active against a battery of virus strains representing the predominant resistance mutations produced by currently available PIs. It has also shown synergistic activity in vitro with Viracept, Crixivan, Norvir and other PIs. AGPH plans to initiate Phase I clinical studies on the compound in ealy 99. Shiongi's S-1153 is further along. It is in Phase I/II and is a supposedly highly potent Non-nucleoside reverse transcriptase inhibitor like Sustiva which has shown in vitro activity against common resistance mutations including ones that Sustiva has shown no activity against. You have to love the strategy. It they don't have it they are buying it. These guys are going for it big time and I am going along for the ride V1.

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