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Biotech / Medical : PFE (Pfizer) How high will it go?
PFE 25.08-2.7%Nov 14 3:59 PM EST
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To: zurdo who wrote (4022)7/8/1998 10:58:00 AM
From: Hunter Vann  Read Replies (1) of 9523
 
Pharmacy Times

Ron Gasbarro, PharmD.

Drugs to treat erectile dysfunction have been in existence for a while. But they involve intracavernous injections and urethral suppositories. An oral drug is infinitely more palatable than a needle prick to the penis. But Viagra will not have the market to itself much longer--at least two new oral medications and a topical gel are in the works. Snickering and late-night jokes aside, impotence can be the result of a more serious condition, such as diabetes or hypertension. These possibilities must be checked out first. Men with impotence problems should also know that sildenafil is not an aphrodisiac. the rest of the body has to want to have sex. More gently, impotence can also be a sympton of nothing more than agin. A pill, such as sildenafil, that can reverse one of the most disheartening signals that one is "over the hill," will certainly please the human race for some time to come.

Sildenafil is a phosphodiesterase (PDE) inhibitor. A PDE is a key enzyme in the regulation of smooth muscle tone. Experimental studies showed that sildenafil specifically palys a key role in the smooth muscle tone of the corpus cavernosum, the two parallel columns of erectile tissue forming the dorsal part of the body of the penis. In an organ bath, strips from human and rabbit corpus cavernosum were precontracted and increasing doses of various PDE inhibitors were added. The results of the study showed that PDE inhibitors dose-dependently relaxed rabbit and human corpus cavernosum strips. Sildenafil was the PDE inhibitor that worked best on human corpus cavernosum.
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