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Biotech / Medical : Ligand (LGND) Breakout!
LGND 209.02+3.2%3:59 PM EST
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To: Hippieslayer who wrote (22928)7/9/1998 9:05:00 AM
From: Henry Niman  Read Replies (1) of 32384
 
Ligand will also be discussing its G-CSF mimic at a Signal Transduction meeting in San Diego in October:

Discovery and Characterization of a Small Molecule Cytokine Mimic

Peter Lamb, Ph.D., Associate Director, Transcription Research, Ligand Pharmaceuticals

Using a cell-based screen that detects activated STATs, we at Ligand Pharmaceuticals have identified a non-peptidyl small molecule that selectively mimics a protein cytokine. This compound is active in multiple assays of cytokine activity in vitro and in vivo. The mechanism of action of the compound will be discussed. Identification of this compound provides proof of principle for drug discovery using JAK/STAT-based assays, and shows that a small non-peptidyl molecule can trigger the activation of a large protein receptor.
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