Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 212.03

+1.4%

2:00 PM EST

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To: Hippieslayer who wrote (22928)	7/9/1998 9:24:00 AM
From: Henry Niman	Read Replies (2) of 32384

At the same conference, LGND exclusive consultant, Ron Evans, will talk about some novel ligands for PPARgamma and potential applications for atherosclerosis: Nuclear Receptors in the Genesis and Treatment of Diabetes and Atherosclerosis Ronald M. Evans, Ph.D., Investigator, Howard Hughes Medical Institute Professor, The Salk Institute for Biological Studies This talk will describe the recent studies on the characterization of ligands for the PPAR class of orphan nuclear receptors. Surprisingly, oxLDL activates PPAR[gamma] and contains two related oxidized lipids (9-HODE and 13-HODE) as novel PPAR[gamma] ligands. These results directly implicate PPAR[gamma] in macrophage/foam cell differentiation and suggest a likely role in atherogenesis.

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