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Biotech / Medical : Sepracor-Looks very promising

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To: Sleepman who wrote (975)7/9/1998 10:41:00 PM
From: bazer  Read Replies (1) of 10280
 
Dan:
Albuterol is over prescribed. As you stated its used many times because it might prove beneficial. You also stated it has very low toxicity. While this may be true in the short run (I've used Albuterol continuously in the ER in a nebulizer over a period of many hours to break a Status Asthmaticus attach with little problems) what about long term use? According to data presented at the ALA/ATS conference patients who had chronic exposure to Albuterol showed negative changes in pre-dose lung function while patients treated with Levalbuterol showed a significant improvement in pre-dose lung function! What about all the patients with mild COPD and CHF that are given Albuterol inhalers and use them every time they become SOB in spite of the shortness of breath being caused by cardiac problems? Placebo affect! Could this not be causing a deterioration in there lung function? If your going to over-prescribe go for the safe route Levalbuterol. Now as far as reactive airway disease patients treated with Levalbuterol at 1.25mg compared to the standard dose of 2.5mg Albuterol showed the greatest increase in FEV(1)with fewer side effects on heart rate potassium and glucose. Yes cost does matter but my felling is that Xopenex offers so many advantages that it will be quickly accepted.
BAZER
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