>>What am I missing?<<
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In your enthusiasm to find an inconsistency in George's and my statements, how about you seem to be ignoring what I wrote. So, just for you, I broke out my crayon set to recompose:
Some bacteria are composed of lipopolysaccharide. As long as the bacteria are composed of lipopolysaccharide, BPI will bind to the bacteria's lipopolysaccharide, and even if BPI does not kill the bacteria that are composed of lipopolysaccharide, it will neutralize the lipopolysaccharide endotoxins caused by the bacteria's death, that is to say, the bacteria made of lipopolysaccharide that die and give off lipopolysaccharide endotoxins. Not all bacteria are composed of lipopolysaccharide, Not all endotoxins are composed of lipopolysaccharide, not all endotoxins come from bacteria, so George is correct that BPI does not bind up all endotoxin.
I'm looking forward to your post with detailed analysis of all gram-negative bacteria and their genetic make-up. |