Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 206.01

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Nov 19 3:59 PM EST

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To: Void who wrote (23204)	7/15/1998 5:33:00 PM
From: Henry Niman	Read Replies (4) of 32384

Void, I have now had a chance to read the entire article and the quote that you posted is really the only info on species specificity. I have re-read the paragraph and Rosen does seem to be just talking about SB247464, when he discusses the mouse specificity. When he talks about the "several drawing boards", he does not indicate that they have not found a human-active compound when these other avenues were explored. The article does address your question about SB247464 moving into the clinic, and LGND indicates that the molecule will be used to explore its mechanism of action (in mice) and its structure will provide a prototype to find related molecules that are human-active. As I said in February, I think that LGND does have a human-active compound(s) and it is in pre-clinical testing (which seems to be borne out by the pipeline table at home.att.net which indicates that a compound has been identified and SELECTED. Robinson's comments on SBH "gobbling up" LGND's targets also supports the conclusion that the programs offer considerable promise and they are move forward and expanding at a rapid rate.

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