Janice,
Please don't quote me out of context. Yes, unattached single strand DNA does have a very short half life in the cell. This is the core of the antisense delivery problem, among others. The CYGS process, as I have said, DOES NOT leave single strand DNA unattached.
During mitosis, cell division, single strand DNA obviously occurs in the division products. It is at this time that single strand DNA, according to the included RNA template, is spliced into the cell DNA by the CYGS vector. The half life of unattached DNA is irrelevant to the CYGS process, though as I said is very relevant to its medical value.
I appreciate all informed information on this company and their technology, but please let's make sure it is informed and complete and not just "the sky is falling" or "everyone knows the world is flat" variety. Christian's opinion, if he follows up with the company, will be interesting.
Graham |
