Reply from Christian below, he does get it. The standard clinical problems he mentions are real and, of course, the subject of much current work by antisense companies.
Also, anyone wanting info on shrimp viral diseases, see link below:
duke.usask.ca
Graham
"Thank you for posting my comments....If the strand does get spliced in during mitosis, it could
circumvent the degradation aspect of the problems mentioned. However, I think all other
problems still stand. Target specificity, target dose, gene product dose, etc. Also, from what I
understand, the telomere is a highly unstable area. One theory on aging is that we gradually
lose our telomeres throughout life, thus causing DNA deterioration as a whole eventually. Also,
there aren't as many genes towards the telomere. Will it actually get expressed? And again, will
it get spliced into another gene of importance causing it's disruption.....not sure how specific
they planned for this event. And because of the telomere unstability will it get lost over time and
thus lose it's ability to deliver it's "drug"? Just some more questions I have....
Thanks again,
Christian" |
