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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: ALL who wrote (5015)7/29/1998 12:05:00 PM
From: tommysdad  Read Replies (1) of 6136
 
One big pill. A worthy idea, but it usually doesn't work, for many reasons. Here are a few (all generic, not necessarily applicable to Viracept).
Taking it: ever try to take a really big pill? It's hard to do. The gag reflex and all.
Absorption: one big pill has less surface area than several small ones, thus the time to "free up" the drug from the incipients is longer. In addition, PI's aren't the most stable of molecules: the rate of dissolution is probably key, and more easily controlled with several pills.
Pharmacokinetics: it is not at all uncommon to see better systemic exposure from, say, 50 mg 3 times a day than from 100 mg twice a day. In other words, less drug taken more frequently actually results in more drug actually finding it's way to the site of action. Very common. So even if one took one big pill twice a day, the drug levels right before the next dose may be so low as to let the genie (HIV) out of the bottle (being controlled by drug).

So, are you the guy everyone posts to all the time ("To all:") . . .
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