Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 206.36

+1.4%

Nov 26 3:59 PM EST

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To: Hippieslayer who wrote (24060)	8/6/1998 1:20:00 PM
From: Henry Niman	Read Replies (1) of 32384

Bob, I think that the new site has quite a bit of info and I'll definitely link relevant portions to Links to Ligand. Here's what I just posted to the diabetes listserve: Ligand Pharmaceuticals has finally put up their web site at ligand.com It has quite a bit of info on their new drugs for treating diabetes. Some of the info can be found at ligand.com I have linked this site to the Diabetes Resources page that I have started at home.att.net I will be linking additional relevant info from the Ligand website. It sounds like the Phase II European results will be released by the end of this year and Lilly should be starting US trials for Targretin soon, and they will also be filing an Investigational New Drug application for one of the second generation rexinoids, LGD1268 or LGD1324 soon. I think that the Targretin works well to increase insulin sensitivity, but at high doses it can cause triglycerides to rise. Ligand is currently reducing dosage to maintain the insulin sensitization properties without increasing triglycerides. I'm not sure if the US Targretin trials will be monotherapy, combination therapy (with Rezulin, Metformin, or Insulin), or both.

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