Even their latest patent won't help:
United States Patent
5,786,178
Niman, et. al.
Jul. 28, 1998
Polypeptide-induced monoclonal receptors to protein ligands
Inventors:
Niman; Henry L. (Carlsbad, CA); Lerner; Richard A. (LaJolla, CA).
Assignee:
The Scripps Research Institute (La Jolla, CA).
Appl. No.:
300,068
Filed:
Sept. 2, 1994
Related U.S. Application Data
Continuation of (including streamline cont.) Ser. No. 772,702, Oct. 7, 1991, abandoned, which is a continuation of Ser. No.
736,545, May 21, 1985, abandoned, which is a continuation-in-part of Ser. No. 701,954, Feb. 15, 1985, Pat. No. 5,030,565.
Intl. Cl. :
C12P 21/04
Current U.S. Cl.:
435/69.6; 435/172.3; 435/240.27; 435/70.2; 435/70.21; 436/518;
530/387.7; 530/388.8; 530/389.7; 935/15
Field of Search:
435/69.6, 240.27, 320.1, 172.3, 70.2, 70.21; 530/387, 389, 388.1,
388.2, 388.8; 935/12, 15; 436/518
References Cited | [Referenced By]
Other References
Lerner, Nature 299: 592-596 (1986) Tapping the Immunological Repetoire to Produce Antibodies.
Niman et al, PNAS 80:4949-4953 (1983) Generation of Protein-Reactive Antibodies by Short.
Primary Examiner: Scheiner; Laurie
Assistant Examiner: Stucker; Jeffrey
Attorney, Agent or Firm: Lyon & Lyon LLP
Abstract
Monoclonal receptors raised to immunogenic polypeptides whose amino acid residue sequences correspond to sequences of
oncoprotein ligands are disclosed, as are method for the production of those receptors and products and methods that utilize them.
The monoclonal receptors bind both to the oncoprotein ligand to a portion of which the polypeptide corresponds in sequence, and to
the immunogenic polypeptide to which the receptors were raised.
11 Claims, 34 Drawing Figures
This invention was made with government support under Public Health Service Contract NO1-CP-41009, Public Health Service
Grants CA 38160 and CA 25803 awarded by the National Institutes of Health. The government has certain rights in the invention.
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