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Microcap & Penny Stocks : Cryogenic Solutions Inc. (CYGS)
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To: celeryroot.com who wrote (3211)8/19/1998 10:00:00 PM
From: Graham Marshman   of 4028
 
SI acting a little wierd tonight. Anyway, Celery, I finally had a chance to look at Inex. Looks like they're using liposome encapsulation for delivery, a technique that has been known for a while. Some comments below, from Davidson College, on this and other known delivery methods. Graham Inserting Antisense into Cells: Endocytosis- One of the simplest methods to get nucleotides in the cell, it relies on the cell's natural process of receptor mediated endocytosis. The drawbacks to this method are the long amount of time for any accumulation to occur, the unreliable results, and the inefficiency (Dantus 1997). Micro- Injection- As the name implies, the antisense molecule would be injected into the cell. The yield of this method is very high, but because of the precision needed to inject a very small cell with smaller molecules only about 100 cells can be injected per day (Dantus 1997). Liposome Encapsulation- This is the most effective method, but also a very expensive one (Dantus 1997). Liposome encapsulation can be achieved by using products such as LipofectACE(TM) to create a cationic phospholipid bilayer that will surround the nucleotide sequence. The resulting liposome can merge with the cell membrane allowing the antisense to enter the cell. Electroporation- The conventional method of adding a nucleotide sequence to a cell can also be used. The antisense molecule should traverse the cell membrane after a shock is applied to the cells.
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