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Biotech / Medical : PFE (Pfizer) How high will it go?
PFE 25.08-2.7%Nov 14 3:59 PM EST

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To: Anthony Wong who wrote (5126)8/24/1998 11:21:00 AM
From: Anthony Wong  Read Replies (2) of 9523
 
More info from Dow Jones about obesity drug development:

Obesity drugs haven't had stellar results in the
marketplace lately. Roche Holding Ltd.'s Xenical, for
instance, is in regulatory limbo at the Food and Drug
Administration. Roche last year withdrew its marketing
application to address FDA concerns about a possible
link between the drug and breast cancer. In May, the
FDA issued conditional approval for the drug but Roche
must take other steps before it can win final approval.

Nearly a year ago, American Home Products Corp.
pulled its obesity drugs Redux and Pondimin off the
market after the drugs were linked to heart valve and
lung diseases

Pfizer's other obesity research focuses on
neuropeptide-Y, a brain chemical that is the most potent
stimulator of feeding ever discovered. In recent years,
researchers have discovered the receptors in the brain
that "hear" neuropeptide-Y's signal. By blocking the
receptors, Pfizer and other drug makers could create
drugs that shut off carbohydrate cravings.

Other obesity drug development efforts target leptin, a
hormone secreted by fat cells that is believed to send a
signal to the brain that enough fat has been stored and a
person should stop eating.

smartmoney.com
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