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Biotech / Medical : XOMA. Bull or Bear?
XOMA 31.98-1.0%11:37 AM EST

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To: Bluegreen who wrote (7157)9/3/1998 3:58:00 PM
From: Edward Paule  Read Replies (2) of 17367
 
B'green,

I agree with you. I speculated about the DSMB September meeting back in post #6398 on 6/1/98:

Message 4670266

Basically, the original trial design had only two scheduled interim analysis looks by the DSMB. At the second review, the DSMB itself suggested that a third look occur in September. My speculation was that the DSMB knew the data was good, but refrained from stopping the trial because they only had 130 patients. They knew that if the data remained good that 200 patients (September) it would be statistically significant enough to stop the trial. They felt it would be unethical to allow the trial to run through December.

IMO,
Ed.
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