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Biotech / Medical : IMAT - ultrafast tomography for coronary artery disease
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To: stock bull who wrote (2700)9/7/1998 6:22:00 PM
From: Brian Moloney  Read Replies (2) of 3725
 
I think that I have talked about this before. There are excellent monkey studies (I believe rhesus) that show reversal of coronary disease with lowering of cholesterol. Of course these monkeys were artificially fed high fat diets to provoke the atherosclerosis in the first place. It is possible then that the resulta might not be applicable to humans. The human studies are not prospective (that is they have not deliberately caused atherosclerosis in humans, but there is a lot of evidence that lowering cholesterol can cause reversal of lesions. Usually it is the LDL that is the benchmark and the goal is to get it less than 100 for sure, perhaps less than 90. The problem with the studies so far has been availability of subjects. One would have had to have a cath at "baseline", decrease the LDL, and then have another cath later. Not a lot of people like to have "unnecessary" caths and there are lots of problems with the "control" group. One of the big reasons that the National Heart-Lung Institute is putting up $60 million plus to study EBCT is to look for a non-invasive way to quantitate reversal of disease after manipulation of risk factors. I hope this helps.
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