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Biotech / Medical : VD's Model Portfolio & Discussion Thread
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To: nigel bates who wrote (5594)9/9/1998 3:19:00 AM
From: Rocketman  Read Replies (1) of 9719
 
I'm not so sure this is that relevant to blood/brain barrier crossing. However through nasal delivery, you can avoid the evils of delivering via the digestive system (acidic conditions with digestive enzymes and hot peppers, pizza and beer attacking the drugs), the problems of getting into blood with intramuscular injections, the difficulty of having patients do their own intravenous injections, the hassle with injections in general and still get drugs into the blood stream fairly regularly and reliably. When I was in college in the early 80's they tried intranasal ADH (anti-diuretic hormone) on me when the docs were suspicious that I was deficient in it (I drink a LOT of water). Had a little curved tube that I'd suck up about 5 microliters into, and then stick one end in my nose and blow into the other. Only took it a few times as it made me sick as a dog, couldn't eat or drink, felt like I had a rubber stomach and gave me a booming headache. The conclusion was that I must not be deficient and that I liked to drink lots of water (medicine by trial and error, kind of like auto mechanics). It was a great way to deliver a sensitive hormone that couldn't take the digestive tract and required just a very small dosage - convenient and painless. Getting the hang of blowing in the tube while inhaling with your nose was a bit tricky but not insurmountable. It is not new as a delivery means as snuff sniffers have known for centuries. Nasal delivery has been around a long time. It is just getting better at getting more difficult molecules into the blood stream thus opening up previously unviable therapies.

Rman
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