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Biotech / Medical : ARIAD Pharmaceuticals
ARIA 23.990.0%Feb 17 4:00 PM EST
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To: Mike McFarland who wrote (350)10/4/1998 7:40:00 PM
From: Mike McFarland  Read Replies (1) of 4474
 
A simple altavista search turns up many references
to NF-kB. So...I really don't know what to make out
of "ARIAD is pursuing a series of related patent
applications on NF-kB to which it holds an exclusive license."

ataxia-telangiectasia mutant
vmmc.org
Recent evidence presented by Jung and Dritschilo implicates the NF-kappaB and IkappaB-alpha proteins in ATM function; the ATM protein appears to phosphorylate IkB-alpha, thereby activating the transcription factor NF-kappaB. These findings would also support observations of increased radiation-induced apoptosis in cell lines derived from A-T patients.

The anticancer drug taxol (paclitaxel) inhibits tumors
cancer-info.com
Gel shift assays demonstrate that paclitaxel causes a marked increase in protein binding to the NF-kappaB and AP-1 consensus binding sequences in the paclitaxel-responsive ovarian cells, but not the nonresponsive cells.

TNF signal transduction is mediated by TRAF2 which binds the TNF Receptor2 (TNFR2) and activates NFkappaB.
library.genetics.nature.com
Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway
Frédéric Relaix1, Xiao-jun Wei2, Xiangwei Wu2 & David A. Sassoon1

Because of some the genes involved in the inflammatory response are regulated by NF-kappaB, the authors have examined the effect of salicylates on NF-kappaB activity.
asmanet.com

...back to my book, hehe.
--MM
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