I think this study has been published only recently and might be of interest to posters.
TI: Efficacy and safety of oral sildenafil in the treatment of
erectile dysfunction: A double-blind, placebo-controlled study
of 329 patients
AU: PadmaNathan_H, Steers_WD, Wicker_PA
NA: UNIV SO CALIF,DEPT UROL,MALE CLIN,1245 16TH ST,SUITE 312,LOS
ANGELES,CA,90404 MALE CLIN,SANTA MONICA,CA
UNIV VIRGINIA,DEPT UROL,CHARLOTTESVILLE,VA
PFIZER INC,PFIZER CENT RES,GROTON,CT,06340
JN: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 1998, Vol.52, No.6,
pp.375-379
IS: 1368-5031
DT: Article
AB: The efficacy and safety of oral sildenafil citrate for the
treatment of erectile dysfunction (ED) were assessed in a 12- week placebo-controlled study. Men with ED of organic,
psychogenic, or mixed aetiology were randomised to placebo
(n=166) or 50 mg sildenafil (n=163), with adjustment to 100 mg
or 25 mg based on efficacy and tolerability. Efficacy
assessments included a global efficacy question, event log
data, and an optional partner questionnaire. At the end of the
study, improved erections were reported by 74% of patients
receiving sildenafil versus 16% for placebo (p<0.0001). In the
final 4 weeks of treatment, 65% of all attempts at sexual
intercourse were successful for all patients (responders and
non-responders) receiving sildenafil versus 20% for placebo
(p<0.001), The mean number of successful attempts per month was
5.9 for patients receiving sildenafil versus 1.5 for those
receiving placebo (p<0.0001). The most common adverse events -
headache, Rushing, and dyspepsia - were generally mild to
moderate in nature and rarely (<1%) a reason for
discontinuation of treatment. Oral sildenafil is an effective,
reliable and well-tolerated treatment for ED of organic,
psychogenic or mixed aetiology.
|
