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Biotech / Medical : EntreMed (ENMD)
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To: DavidCG who wrote (1322)10/24/1998 10:15:00 PM
From: muddphudd  Read Replies (1) of 2135
 
To All,

Within the last few days I had a conversation with the chief of neurosurgery at Brigham & Women's Hospital. They are teaming up with Folkman (next door at Children's Hospital) to start trials using a viral vector to introduce endostatin/angiostatin into brain tumors (specifically, glioblastomas). The idea is that since Endostatin and Angiostatin have short half-lives, they can overcome this problem by infecting tumor cells with a vector that drives expression of these anti-angiogenesis molecules. Whether it will work, who knows. My impression of gene therapy (which is essentially what this is) is that is far from being a tangible therapeutic vehicle. Nice idea though.
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