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Biotech / Medical : XOMA. Bull or Bear?

XOMA 32.90

+2.8%

1:35 PM EST

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To: Robert K. who wrote (7523)	10/26/1998 9:12:00 PM
From: Robert S.	Read Replies (2) of 17367

As always, Cacaito, appreciate your comments and the associated information. Robert K, one area of skepticism (regarding BPI) is the administration time-frame of this pharmaceutical compound. A study performed with rats (Jin, et al.,1995) revealed that BPI therapeutic efficacy decreases rapidly with respect to time of administration relative to contagion onset. Taking into account the accelerated physiological processes of rats, BPI given immediately or 30 minutes after LPS injection proved therapeutic but BPI given 2 hours after LPS injection produced no protective effect. In another study, this one with mice (Kelley, et al.,1993) BPI produced a 95% survival rate when administered immediately after E.coli inoculation but this survival rate decreased to 65% when 2 hours elapsed before BPI administration. Timing does indeed seem to be a critical issue and one has cause to ponder how efficacious BPI will be when utilized under uncontrolled "real world" conditions.

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