I guess that researcher has a right to their opinion. I dont go for the
(role of endotoxin in doubt) theory of his.
I do agree with his first statement though>
>There is strong evidence to implicate endotoxin released from gram negative bacteria in the pathogenesis of the sepsis syndrome and related conditions<
IMO
Equally perplexing is the role of the bodys OWN NATURAL bpi in the sepsis syndrome..I ask, why is this so? Why their conclusion?
>
>Pediatr Infect Dis J 1995 Dec;14(12):1087-91
Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome.
Wong HR, Doughty LA, Wedel N, White M, Nelson BJ, Havrilla N, Carcillo JA
Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh School of Medicine, PA, USA.
Bactericidal/permeability-increasing protein (BPI) is a neutrophil azurophilic granule component that is bactericidal towards Gram-negative bacteria and inhibits lipopolysaccharide-mediated inflammatory responses. We conducted a prospective study to measure plasma BPI concentrations in 36 critically ill children with and without the sepsis syndrome. Plasma BPI concentrations ranged from 0.5 to 452 ng/ml. Patients with the sepsis syndrome had higher median plasma BPI concentrations than critically ill controls (5.1 vs. 1.8 ng/ml, P = 0.006). Patients with organ system failure had higher median plasma BPI concentrations than those with no organ system failure (4.5 vs. 1.3 ng/ml, P = 0.001). Plasma BPI concentrations were positively associated with pediatric risk of mortality score (P = 0.03, rs = 0.4). These data provide the first clinical insights regarding the role of endogenous BPI production in critically ill children and suggest that BPI may play an important role in host defenses. |
