Robert S, it is a review, not an original work, the bottom of the reference specify it.
Your reference is a very good review. This is very important to sit down and learn. But, one will not get a new development from it.
It is the difference between reviewing the work of Kenneth Starr or actually doing the investigation. Everybody has an opinion about it, but He did the work.
Holzheimer refers to certain recent works against the evidence that suppressing endotoxins is not worth it, well that probably is referring to other failures we have review before (E5, antiTNF, Cento drug....),
What does that has to do with BPI, did he included BPI "failures" as evidence, Not. I do not have the full printed version, I do not know what does he refer to.
And, he proposed about the L-Forms, interesting but I could proposed that BPI will not give a chance for bacteria to form L-forms, they will be long dead before that, since BPI is so early in the killing that there is not chance for bacteria to activate other mechanisms, Not feasible, then prove it the other way.
You are right in one sense, you are skeptical of a work in progress. But everybody here since to be too, that is why Xoma is 10% of my portfolio, I could not tolerate a bigger loss (I mean bet).
Patience, in couple of month we will have the results. |
