Cacaito, I value your opinions and would like to hear your comments on the contradictory evidence pertaining to endotoxins and septic shock. The following journal abstract review is a case in point:
Infect Agents Dis 1993 Feb;2(1):35-43
Endotoxin as a therapeutic target in septic shock.
Corriveau CC, Danner RL
Critical Care Department, Children's National Medical Center, Washington, D.C.
Endotoxin initiates a broad inflammatory response in mammals that has many similarities to de novo septic shock in patients. The presumed role of endotoxin
in septic shock has led to the investigation of antiendotoxin therapies for the treatment of this syndrome. However, a causative role for endotoxin in human
septic shock has not been established. Recent information about the biochemistry of endotoxin, mechanisms of endotoxin-induced cell activation, and the
pathogenesis of septic shock has provided insights useful to the development of new antiendotoxin agents, but also has raised concerns about the suitability of
endotoxin as a therapeutic target. Definitive proof of the pathogenic importance of endotoxin in human septic shock will depend upon demonstrating that a
putative antiendotoxin therapy has clinical efficacy.
Publication Types:
Review
Review, tutorial
PMID: 8162352, UI: 94214877 |
