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Biotech / Medical : Pharma News Only (pfe,mrk,wla, sgp, ahp, bmy, lly)
PFE 25.88+1.5%3:59 PM EST

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To: Henry Niman who wrote (984)11/4/1998 12:40:00 PM
From: Anthony Wong  Read Replies (1) of 1722
 
Monsanto Scales Back Heart Drug Trial, Cites Early Deaths

Bloomberg News
November 4, 1998, 12:07 p.m. ET

Monsanto Scales Back Heart Drug Trial, Cites Early Deaths

Washington, Nov. 4 (Bloomberg) -- Monsanto Co.'s Searle drug
unit said it scaled back a study of its clot-preventing heart
drug after seeing a greater than expected number of deaths.

One of the two groups of patients getting the drug had an
unexpectedly high rate of deaths within the first 30 days of
taking the drug. The company said it won't enter any more
patients into the study, though treatment will continue for those
patients who already have gotten through that 30-day period.

The drug, known as orbofiban, is an oral version of a class
of drugs that have become well accepted among cardiologists.
Centocor Inc., Cor Therapeutics Inc. and Merck & Co. sell the
currently approved drugs in the class, which analysts say could
have sales of $1 billion a year or more.

Shares of St. Louis-based Monsanto fell 2 15/16 to 39 1/2 in
recent trading. The company, one of the world's largest makers of
herbicides and technology used to improve crops, is undergoing a
transformation to focus on drugs and agricultural biotechnology.

The company said it ended enrollment of new patients into
the study as ''a precautionary measure.'' More than 8,000
patients already enrolled in the study will continue to be
monitored, the company said. The independent monitoring board
that oversees the study said factors other than the drug may have
contributed to the higher-than-expected death rate.

Another similar drug under study by the company, known as
xemilofiban, isn't affected by this move, Monsanto said.

--Kristin Jensen and Kristin Reed in the Washington newsroom
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