Current holders as of 31 Aug. 98 in DEF14A filed on 13 Oct. 98: Cobe Laboratories, Inc.(4)................................... 3,214,199 20.2% 1185 Oak Street Lakewood, CO 80215 The Kaufmann Fund, Inc. ..................................... 2,101,518 13.2 140 East 45th Street, 43rd Floor New York, NY 10017 State Treasurer of the State of Michigan(5).................. 1,408,168 8.9 Custodian of Certain Retirement Systems c/o Venture Capital Division 430 West Allegan Lansing, MI 48992 Pfizer, Inc. ................................................ 864,546 5.4 235 East 42nd Street New York, NY 10017 R. Douglas Armstrong, Ph.D.(6)............................... 966,506 5.9 Stephen G. Emerson, M.D., Ph.D.(7)........................... 167,583 1.1 Mary L. Campbell(8).......................................... 95,416 * Robert J. Kunze(9)........................................... 103,060 * James Maluta(10)............................................. 127,333 * Todd E. Simpson(11).......................................... 55,626 * Alan K. Smith, Ph.D.(12)..................................... 59,834 * Horst R. Witzel, Dr.-Ing.(13)................................ 22,916 * Edward C. Wood, Jr.(14)...................................... 3,226,782 20.3 All officers and directors as a group (11 persons)(15)....... 4,825,056 29.0 |