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Biotech / Medical : Centocor ( CNTO )

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Mar 7 3:00 PM EST

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To: FNS who wrote (843)	11/23/1998 10:51:00 AM
From: Henry Niman	Read Replies (3) of 965

I don't think that there is a "pill form". Remicade is a monoclonal antibody (which is a large protein) and therefore must be given via infusion. I think that the earlier versions were distributed in liquid form, while the latter were a dried powder form (which still has to be dissolved in a saline like solution and infused). I think that the problems arose fairly recently when patients who had been treated several years ago were re-infused recently. I have to check, but suspect that the adverse effect is an allergic reaction and the patient is sensitized by the initial injection(s) and then develops a more powerful response when challenged at a later date.

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