Hi Jacq
Just received an info pac from BIO.
Very interesting in that Diab II was discovered by research on another project.
"V-411 is the first of a new class of diabetic drugs. It was discovered in the research of a Canadian company, Biotech Holdings, Ltd in Vancouver (1992). Scientists were working on Human Choronic Gonadotropin at the time and not in diabetes at the time."
I heard that great finds are often discovered this way. Here is hoping.
The literature is interesting.
There was reference to Help for Diabetes type I as well in that (if I understand correctly)it aids in the binding of insulin to the cells making the insulin last longer. I may have understood this wrong.
>>This is from Deutsche Morgan Grenfell report, Apr. 22, 1998
Other Insulin Sensitizers
Diab II: an insulin sensitizer with a novel mechanism of action
THE ONLY INSULIN SENSITIZER THAT IS NOT A PPAR AGONIST IS BIOTECHS HOLDINS' DIAB II
Diab II is a small molecule which enhances the binding of insulin to its cells surface receptors and their subsequent internalisation. thus cells are effectively resensitized to the actions of insulin, promoting the internalisation of glucose storage and utilisation. Diab II benefits from the same advantages that the PPAR agonists enjoy over sulphonylureas, including an effective reduction in the levels of cholesterol and fats circulating in the blood, which reduces the risk of atherosclerosis and coronary heart disease.
Further more there are no reports of any problematic side-effects since marketing of the product since marketing in China in Feb. 1997
With a suitable marketing partner, the outlook for DiabII appears extremely promising, especially if further liver side effects problems with the PPAR agonists are discovered. Biotech Holdings plans to launch the product in South America and the Carribean by the end of 1998. Discussions are undeway to find partners in North America, Europe and Japan.<<
Do you have any negative thoughts here. So far I've liked what I've read. It would be nice if they could get funding from The Juvenile TypeI people, To see if DiabII would be benefit to Type I diabetes.
Maybe that is in the future works. |
