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Biotech / Medical : XOMA. Bull or Bear?
XOMA 31.65+2.2%12:34 PM EST
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To: Robert K. who wrote (7941)12/4/1998 3:36:00 PM
From: Robert S.  Read Replies (3) of 17367
 
"Now let me get this strait, you are saying that bacteria produce toxins
and you are saying that neutralization or attenuation of these toxins
may not be beneficial. In fact, you are saying that this is a matter of
>CONSIDERABLE< controversy. OK dude, whatever you say.
I wonder what Girior or Opal or and other DR would say about that!
Geez, elimination of a foreign toxin is not helpful.>>>>>>Pleeease.."

Excerpted from (Holzheimer, 1998):

The hypothesis that neutralization of endotoxin and pro-inflammatory cytokines
is beneficial in sepsis was seriously challenged by the results of recent clinical
and experimental studies.

Excerpted from (Natanson et al., 1994):

Targeting a single microbial toxin
such as endotoxin may not represent a viable strategy for treating a
complex inflammatory response to diverse gram-negative bacteria. Similarly, the
strategy of inhibiting the host inflammatory response may not be beneficial
because immune cells and cytokines play both pathogenic and protective roles. Finally,
our scientific knowledge of the complex timing of mediator release
and balance during sepsis may be insufficient to develop successful therapeutic
interventions for this syndrome.
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