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Biotech / Medical : Monsanto Co.
MTC 2.800-7.0%Jan 21 3:59 PM EST

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To: John F Beule who wrote (790)12/22/1998 8:48:00 AM
From: John F Beule  Read Replies (1) of 2539
 
Major Changes in the Treatment of Osteoporosis, Rheumatoid Arthritis, andRelated Diseases Lie Ahead, According to a Decision Resources Report

WALTHAM, Mass., Dec 18 /PRNewswire/ -- The Outlook for Bone and Connective Tissue Disease Therapy Markets, a new DR Report from Decision Resources, is a timely study that discusses new approaches to treating a broad range of bone and connective tissue diseases, and their potential impact on sales in their relevant therapeutic group.

We predict the following developments:

-- Direct sales of drugs to treat bone and connective tissue diseases will

reach $25 billion annually by 2007.

-- Improved COX-2-specific NSAIDs such as celebrex (celecoxib) from Searle

and rofecoxib (vioxx) from Merck will likely be launched in 1999 and

2000, respectively. These NSAIDs are designed to relieve pain and

inflammation in autoimmune diseases and osteoarthritis with reduced GI

side effects. In 2001 we will see the launch of NSAIDs with a more

potent analgesic effect -- eltanac from Byk Gulden and tinoprofen from

Japan Tobacco.

-- An increasing commitment to identify genomic aberrations and translate

the findings into new approaches for diagnosis and therapy.

-- Commercial development of TNF antagonists for severe rheumatoid

arthritis will continue to be focused on drugs such as Immunex's Enbrel

(etanercept) that antagonize the action of the cytokines rather than

chemokines.

-- We expect a steady convergence of therapies that are used for a variety

of autoimmune diseases and which have the same basic origin of immune

system dysfunction. As the convergence plays out, certain drugs found

to be multi-indicational will see dramatic sales growth potential.

This hypothesis is well illustrated in the case of Arava (Hoechst

Marion Roussel), recently approved for rheumatoid arthritis and now in

clinical trials for lupus.

-- The use of immunosuppressive drugs (predominantly methotrexate and

cyclophosphamide) for control over the progression of autoimmune

disease will increase significantly during the next decade.

Journalists, contact: Cindy Corona, phone 781-487-3721, e-mail corona@dresources.com.

Sales inquiries, contact: Jean Carbone, phone 781-487-3737, e-mail drreports@dresources.com. This report is available for $3200.00.

DR Reports analyze technological advances, regulatory developments, and business trends in the health care industry. Decision Resources was founded as a subsidiary of Arthur D. Little, Inc., and is now an independent, employee-owned health care research and consulting firm.

SOURCE Decision Resources

CO: Decision Resources

ST: Massachusetts

IN: MTC

SU:

12/18/98 09:47 EST prnewswire.com
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