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Biotech / Medical : XOMA. Bull or Bear?
XOMA 31.10+0.4%3:59 PM EST
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To: aknahow who wrote (8130)12/27/1998 12:11:00 PM
From: jackie  Read Replies (1) of 17367
 
George,

Besides the comments regarding BPI, did you notice the reference of nitric oxide in this process?

<<Pseudomonas and other bacterial pathogens bind to the epithelial cell and either initiate or promote the inflammatory response, which may be a complex interplay between decreased nitric oxide activity and increased NF-KB.>>

It seems the next step in understanding the exact sequence of events leading up to an infection with someone suffering from CF is a careful assay of the fluid contents of the airways. If the hypothetical construct being suggested by the authors is correct, one of the contributing factors to the infection is the presence of salt in the fluids, leading to a decrease in BPI concentrations. If true, this suggests the following:

1) Treatment would include lowering the salt levels in the CF airway fluids to discourage anymore destruction of the naturally produced BPI and other anti infective proteins;

2) Administer BPI when a CF patient is contracting an infection.;

3) BPI plays a central role in the body's natural response to the presence of an infective agent in the lungs. Otherwise, why would the body produce it? And why would a decrease in BPI levels be a correlating factor in CF infections?

4) Watch the salts when using BPI. Is BPI sensitive to elevated salt concentrations? If so, could this not be a factor in those cases where BPI appears to be ineffective? In the one fatality we had in the safety study, were their elevated salt levels in the victim?

Regards,

Jack Simmons
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