SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Pharmacopeia, Inc. (ACCL) (Prev: PCOP)
ACCL 4.000-1.2%11:33 AM EST
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: scaram(o)uche who wrote (122)12/27/1998 6:01:00 PM
From: kinkblot  Read Replies (1) of 179
 
Combinatorial Chemistry: Not Just For Pharmaceuticals.

pubs.acs.org

Article reviews application of cc to catalysts, polymers and advanced materials such as phosphors. Some of this is out of PCOP's bailiwick, especially cases where properties depend more on extended solid-state structure than on molecular structure. For example, the Bell Labs dielectric work which involves vacuum deposition of thin films.

The biggest challenge may be coming up with methods to screen for desired physical properties. For catalysts, below is a simple technique for measuring reaction rates using thermographs, compatible with solid-support synthesis:

[excerpt]......
In developing new catalysts, measuring reaction rates is often difficult. At the University of North Carolina, James Morken and graduate student Steven Taylor correlated the reaction rates of a library of 3,150 catalyst candidates supported on resin beads with the amount of heat liberated to the solvent during the reactions. Morken explains, "Police departments use infrared devices to pick up heat produced by children lost in the woods. Similarly, we use a thermographic video camera to find which polymer beads - to which chemicals have been attached - are generating heat. The heat indicates a chemical reaction, and the more heat, generally the better that chemical is as a catalyst." The most active catalysts were those most strongly bound to the beads.
....................

From: Today's Chemist at Work, November 1998.
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News