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Biotech / Medical : ARIAD Pharmaceuticals
ARIA 23.990.0%Feb 17 4:00 PM EST
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To: Mike McFarland who wrote (395)1/1/1999 12:28:00 PM
From: scaram(o)uche  Read Replies (1) of 4474
 
Mike:

Thanks very much for raising this question. It's going to be an important one to have asked.

Here's claim one......

We claim:
1. A composition, comprising:

(a) recombinant AAV virions which comprise an AAV vector containing a nucleic acid molecule
encoding erythropoietin operably linked to control elements that direct the transcription and
translation thereof; and
(b) a pharmaceutically acceptable excipient.

This language clearly covers the ARIA work. I was surprised to see that the priority date was '96, sort of a fresh one.

OTOH, here's the abstract.....

The use of recombinant adeno-associated virus (AAV) virions for
delivery of DNA molecules to muscle cells and tissue in the treatment
of anemia is disclosed. The invention allows for the direct, in vivo
injection of recombinant AAV virions into muscle tissue, e.g., by
intramuscular injection, as well as for the in vitro transduction of
muscle cells which can subsequently be introduced into a subject for
treatment. The invention provides for sustained, high-level expression
of a delivered nucleotide sequence encoding erythropoietin, and for in
vivo secretion thereof from transduced muscle cells such that
systemic delivery is achieved.

Clearly, "sustained, high-level expression
of a delivered nucleotide sequence" is not in the spirit of the ARIA work. It'll be interesting!

Rick
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