| Helix receives patent for drug delivery technology 
 Helix Biopharma Corp                                                    HBP
 Shares issued 13,776,415                                  Jan 6 close $0.33
 Thu 7 Jan 99                                                   News Release
 An anonymous director reports
 A significant composition patent has been issued to the company by the U.S.
 Patent   Office  protecting  the  core  technology  used  in  its  Biphasix
 injectionless drug  delivery  technology.  This  new  patent  adds  to  the
 existing  portfolio  of  intellectual  property, which includes patents for
 drug delivery systems, anti-infective  therapeutics  and  molecular  sensor
 technology.
 The company's Biphasix system,  which  is  capable  of  delivering  a  wide
 variety  of pharmaceuticals of varying sizes, weights and solubilities into
 and through the skin, uses a proprietary,  lipid-based,  microencapsulation
 process.  Preliminary  studies  have  shown  that  the  Biphasix system may
 enhance the availability of drugs in the body, leading to improved clinical
 outcomes.
 This injectionless drug delivery technology is particularly well suited  to
 biologically  derived pharmaceuticals including proteins and DNA, which are
 typically given by injection.
 Helix has successfully conducted studies with a number of  model  compounds
 such  as  insulin,  interferon-a  (widely used in the treatment of a common
 sexually transmitted disease caused  by  the  human  papilloma  virus)  and
 prostaglandin  E(1)  (used in the treatment of erectile dysfunction). These
 initial  applications  have  estimated  potential  markets  in  excess   of
 $4-billion (U.S.) annually.
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